semaglutide mass impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity - Jeromson - The Journal of Physiology Does Semaglutide Reduce Muscle Mass

This increases protein synthesis, decreases protein degradation, stimulates skeletal muscle cell growth, and increases muscle function and strength 10

These mechanisms result in the downregulation of Bcl-2 and NF-B p65, alongside the upregulation of cleaved caspase-3/8 and Bax, ultimately inducing apoptosis in ovarian cancer cells [68]

Physical activity and sleep quality represent two critical lifestyle factors that influence metabolic health, with varying effects on GLP-1 and other regulatory hormones

Plus there is a value play here as well (i.e., look at how much valuable protein Im getting for the price.)

However, the therapeutic efficacy and safety of SM04690 under long-term or repeated dosing remain unverified, and its effects on other joint-resident cells such as synoviocytes and osteoblasts have not been fully explored